Glenn grew up in Georgia and was commissioned as a single missionary to serve with HCJB (now Reach Beyond) in Ecuador in 1981. Bonnie, the daughter of Wycliffe Bible Translators, John and Alice Brawand, grew up in Guatemala among the Rabinal Achí people. Upon graduation from Wheaton College in 1982, she went to Ecuador for a six-month internship combining ethnomusicology with community development. Bonnie and Glenn first met at HCJB in Ecuador, arriving two weeks apart. They were married May 7, 1983.

Since 1989 Glenn and Bonnie have been seconded from Reach Beyond to Inspiracom`s Spanish and English radio and Spanish Bible correspondence ministry along the Mexico/US border. Inspiracom was a ministry of Reach Beyond from 1978 to 2005 when it became a separate but cooperating ministry of Reach Beyond. President of Inspiracom, Glenn completed a PhD in Leadership Studies in 2017.  Bonnie ministers in the areas of music and writing.

The Lafittes have two grown sons, two daughters-in-law, and two granddaughters. Jared and Mandy are parents of Audrey; Justin and Glenna are parents of Grey.